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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_007474.2Â RefSeqGene
- Range
-
5246..11140
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_804
mRNA and Protein(s)
-
NM_000665.5 → NP_000656.1  acetylcholinesterase isoform E4-E6 precursor
See identical proteins and their annotated locations for NP_000656.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (E4-E6) encodes the hydrophilic form of acetylcholinesterase, isoform (E4-E6).
- Source sequence(s)
-
AC011895, AK223443
- Consensus CDS
-
CCDS5709.1
- UniProtKB/Swiss-Prot
- A4D2E2, B7ZKZ0, D6W5X7, P22303, Q16169, Q29S23, Q2M324, Q504V3, Q53F46, Q86TM9, Q86YX9, Q9BXP7
- Related
- ENSP00000241069.5, ENST00000241069.11
- Conserved Domains (2) summary
-
- pfam00135
Location:37 → 563
- COesterase; Carboxylesterase family
- pfam08674
Location:578 → 611
- AChE_tetra; Acetylcholinesterase tetramerisation domain
-
NM_001282449.2 → NP_001269378.1  acetylcholinesterase isoform 3 precursor
See identical proteins and their annotated locations for NP_001269378.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses an alternate splice acceptor site compared to variant E4-E6. The encoded isoform (3) is shorter than isoform E4-E6
- Source sequence(s)
-
AC011895, AF334270, AK223443
- Consensus CDS
-
CCDS64736.1
- UniProtKB/Swiss-Prot
-
P22303
- Related
- ENSP00000403474.2, ENST00000419336.6
- Conserved Domains (2) summary
-
- pfam08674
Location:490 → 523
- AChE_tetra; Acetylcholinesterase tetramerisation domain
- pfam00135
Location:37 → 475
- COesterase; Carboxylesterase family
-
NM_001302621.3 → NP_001289550.1  acetylcholinesterase isoform E4-E5 precursor
See identical proteins and their annotated locations for NP_001289550.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, lacks an exon in 3' UTR and 3' coding region and uses an alternate terminal exon, compared to isoform E4-E6. The encoded isoform (4) is longer and has a distinct C-terminus compared to isoform E4-E6.
- Source sequence(s)
-
AC011895, AI831696, BC105060
- Consensus CDS
-
CCDS5710.1
- Related
- ENSP00000404865.1, ENST00000411582.4
- Conserved Domains (1) summary
-
- pfam00135
Location:39 → 563
- COesterase; Carboxylesterase family
-
NM_001302622.2 → NP_001289551.1  acetylcholinesterase isoform E4-E6 precursor
See identical proteins and their annotated locations for NP_001289551.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) differs in the 5' UTR compared to variant E4-E5. Both variant 5 and E4-E6 encode the same protein (isoform E4-E5)
- Source sequence(s)
-
AC011895, BC094752, DA205851
- Consensus CDS
-
CCDS5709.1
- UniProtKB/Swiss-Prot
- A4D2E2, B7ZKZ0, D6W5X7, P22303, Q16169, Q29S23, Q2M324, Q504V3, Q53F46, Q86TM9, Q86YX9, Q9BXP7
- Related
- ENSP00000414858.1, ENST00000428317.7
- Conserved Domains (2) summary
-
- pfam00135
Location:37 → 563
- COesterase; Carboxylesterase family
- pfam08674
Location:578 → 611
- AChE_tetra; Acetylcholinesterase tetramerisation domain
-
NM_001367915.1 → NP_001354844.1  acetylcholinesterase isoform E4-E6 precursor
Status: REVIEWED
- Source sequence(s)
-
AC011895
- Consensus CDS
-
CCDS5709.1
- UniProtKB/Swiss-Prot
- A4D2E2, B7ZKZ0, D6W5X7, P22303, Q16169, Q29S23, Q2M324, Q504V3, Q53F46, Q86TM9, Q86YX9, Q9BXP7
- Conserved Domains (2) summary
-
- pfam00135
Location:37 → 563
- COesterase; Carboxylesterase family
- pfam08674
Location:578 → 611
- AChE_tetra; Acetylcholinesterase tetramerisation domain
-
NM_001367917.1 → NP_001354846.1  acetylcholinesterase isoform E4-E6 precursor
Status: REVIEWED
- Source sequence(s)
-
AC011895
- Consensus CDS
-
CCDS5709.1
- UniProtKB/Swiss-Prot
- A4D2E2, B7ZKZ0, D6W5X7, P22303, Q16169, Q29S23, Q2M324, Q504V3, Q53F46, Q86TM9, Q86YX9, Q9BXP7
- Related
- ENSP00000394976.1, ENST00000412389.5
- Conserved Domains (2) summary
-
- pfam00135
Location:37 → 563
- COesterase; Carboxylesterase family
- pfam08674
Location:578 → 611
- AChE_tetra; Acetylcholinesterase tetramerisation domain
-
NM_001367918.1 → NP_001354847.1  acetylcholinesterase isoform 5
Status: REVIEWED
- Source sequence(s)
-
AC011895, KF510962
- Conserved Domains (2) summary
-
- pfam00135
Location:104 → 630
- COesterase; Carboxylesterase family
- pfam08674
Location:645 → 678
- AChE_tetra; Acetylcholinesterase tetramerisation domain
-
NM_001367919.2 → NP_001354848.1  acetylcholinesterase isoform 6
Status: REVIEWED
- Source sequence(s)
-
AC011895, KF510962
- Conserved Domains (2) summary
-
- pfam00135
Location:103 → 629
- COesterase; Carboxylesterase family
- pfam08674
Location:644 → 677
- AChE_tetra; Acetylcholinesterase tetramerisation domain
RNA
-
NR_160407.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC011895, KF510962
-
NR_160408.2 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC011895
- Related
-
ENST00000440755.5
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000007.14Â Reference GRCh38.p14 Primary Assembly
- Range
-
100889994..100896994 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060931.1Â Alternate T2T-CHM13v2.0
- Range
-
102130076..102137081 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_015831.2: Suppressed sequence
- Description
- NM_015831.2: This RefSeq was removed because currently there is insufficient support for the transcript. NM_001302621.1 represents a similar splice structure and encodes the same 617 amino acid protein.